Treatment of Sydenham chorea with corticosteroids
Identifieur interne : 003F08 ( Main/Exploration ); précédent : 003F07; suivant : 003F09Treatment of Sydenham chorea with corticosteroids
Auteurs : Francisco Cardoso [Brésil] ; Débora Maia [Brésil] ; Mauro César Q. S. Cunningham [Brésil] ; Guilherme Valença [Brésil]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adolescent, Adult, Anti-Inflammatory Agents (administration & dosage), Anti-Inflammatory Agents (therapeutic use), Chemotherapy, Child, Chorea (drug therapy), Corticosteroid, Drug Administration Schedule, Female, Follow-Up Studies, Human, Humans, Injections, Intravenous, Male, Methylprednisolone (administration & dosage), Methylprednisolone (therapeutic use), Middle Aged, Sydenham chorea, Treatment, Treatment Outcome, anti‐basal ganglia antibody, chorea, methyl‐prednisolone, prednisone, rheumatic fever, steroids.
- MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Methylprednisolone.
- chemical , therapeutic use : Anti-Inflammatory Agents, Methylprednisolone.
- drug therapy : Chorea.
- Adolescent, Adult, Child, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Injections, Intravenous, Male, Middle Aged, Treatment Outcome.
Abstract
Despite treatment with valproic acid and neuroleptics, a significant proportion of patients with Sydenham chorea (SC) remain with chorea. We evaluated the effect of intravenous methyl‐prednisolone followed by oral prednisone in patients with SC refractory to conventional treatment. Patients were enrolled in the study if they failed to improve with conventional treatment, despite the development of side effects. Chorea was rated on a 0 to 4 score. Five patients, 3 of them women, were included in the study. The median pretreatment rating score of the chorea was 3 (range, 3–4) and dropped to 1 (range, 0–2) after a median follow‐up of 7 months (range, 3–7 months). Two patients developed Cushing syndrome. Our data suggest that intravenous methyl‐prednisolone followed by oral prednisone is an effective and well‐tolerated treatment of refractory SC. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10521
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-11">2003-11</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1374">1374</biblScope><biblScope unit="page" to="1377">1377</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D67A21717E49D74965DBEE2DD81CB0DF71E70486</idno><idno type="DOI">10.1002/mds.10521</idno><idno type="ArticleID">MDS10521</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Inflammatory Agents (administration & dosage)</term><term>Anti-Inflammatory Agents (therapeutic use)</term><term>Chemotherapy</term><term>Child</term><term>Chorea (drug therapy)</term><term>Corticosteroid</term><term>Drug Administration Schedule</term><term>Female</term><term>Follow-Up Studies</term><term>Human</term><term>Humans</term><term>Injections, Intravenous</term><term>Male</term><term>Methylprednisolone (administration & dosage)</term><term>Methylprednisolone (therapeutic use)</term><term>Middle Aged</term><term>Sydenham chorea</term><term>Treatment</term><term>Treatment Outcome</term><term>anti‐basal ganglia antibody</term><term>chorea</term><term>methyl‐prednisolone</term><term>prednisone</term><term>rheumatic fever</term><term>steroids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Methylprednisolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Methylprednisolone</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Chorea</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Drug Administration Schedule</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Injections, Intravenous</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chimiothérapie</term><term>Chorée Sydenham</term><term>Corticostéroïde</term><term>Homme</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite treatment with valproic acid and neuroleptics, a significant proportion of patients with Sydenham chorea (SC) remain with chorea. We evaluated the effect of intravenous methyl‐prednisolone followed by oral prednisone in patients with SC refractory to conventional treatment. Patients were enrolled in the study if they failed to improve with conventional treatment, despite the development of side effects. Chorea was rated on a 0 to 4 score. Five patients, 3 of them women, were included in the study. The median pretreatment rating score of the chorea was 3 (range, 3–4) and dropped to 1 (range, 0–2) after a median follow‐up of 7 months (range, 3–7 months). Two patients developed Cushing syndrome. Our data suggest that intravenous methyl‐prednisolone followed by oral prednisone is an effective and well‐tolerated treatment of refractory SC. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Minas Gerais</li></region><settlement><li>Belo Horizonte</li></settlement><orgName><li>Université fédérale du Minas Gerais</li></orgName></list><tree><country name="Brésil"><region name="Minas Gerais"><name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name></region><name sortKey="Cunningham, Mauro Cesar Q S" sort="Cunningham, Mauro Cesar Q S" uniqKey="Cunningham M" first="Mauro César Q. S." last="Cunningham">Mauro César Q. S. Cunningham</name><name sortKey="Maia, Debora" sort="Maia, Debora" uniqKey="Maia D" first="Débora" last="Maia">Débora Maia</name><name sortKey="Valenca, Guilherme" sort="Valenca, Guilherme" uniqKey="Valenca G" first="Guilherme" last="Valença">Guilherme Valença</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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